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This leaflet is part III of a three-part "Product Monograph" published when ZOCOR was approved for sale in Canada and is designed specifically for Consumers. This leaflet is a summary and will not tell you everything about ZOCOR . Contact your physician or pharmacist if you have any questions about the drug. Remember - This medicine is prescribed for the particular condition that you have. Do not give this medicine to other people, nor use it for any other condition. ABOUT THIS MEDICATION ZOCOR is the brand name for the substance simvastatin, available only on prescription from your physician. What the medication is used for: Your physician has prescribed ZOCOR to lower the levels of cholesterol and fatty substances called triglycerides in your blood and to reduce the health risks associated with Coronary Heart Disease CHD ; . Elevated cholesterol can cause CHD by clogging the blood vessels atherosclerosis ; that carry oxygen and nutrients to the heart. If you have CHD or other signs of atherosclerosis such as previous stroke, symptoms of peripheral vascular disease, or diabetes regardless of the amount of cholesterol in your blood ; , ZOCOR should lessen the risk of heart attack or stroke. You can also benefit from taking ZOCOR if you have high levels of cholesterol with or without associated high triglycerides primary hypercholesterolemia, or combined hyperlipidemia ; and homozygous familial hypercholesterolemia high cholesterol inherited from both parents ; . As part of your treatment plan to lower cholesterol, and depending on your health and lifestyle, your physician may recommend a diet to reduce cholesterol and other measures such as exercise and weight control. What it does: Simvastatin is one of the class of medicines known as HMG-CoA reductase inhibitors. They inhibit, in other words block, an enzyme that is necessary for the body to make cholesterol. In this way, less cholesterol is produced in the liver. Medicines like this one are prescribed along with, and not as a substitute for, a special diet and other measures. Simvastatin is used to lower the levels of cholesterol [particularly low-density lipoprotein cholesterol LDL-C ; ] and fatty substances called triglycerides in your blood. ZOCOR reduces the amount of cholesterol in your blood. Elevated cholesterol can cause CHD by clogging the blood vessels that carry oxygen and nutrients to the heart. When it should not be used: Do not take ZOCOR if you are: allergic to any of its components diagnosed with active liver disease pregnant or breast-feeding What the medicinal ingredient is: Simvastatin What the important nonmedicinal ingredients are: Ascorbic acid, butylated hydroxyanisole, citric acid, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, micro crystalline cellulose, pregelatinized starch, talc, and titanium dioxide. Tablets ZOCOR 5 mg, 10 mg and 20 mg contain yellow ferric oxide. Tablets ZOCOR 10 mg, 20 mg, 40 mg and 80 mg also contain red ferric oxide. What dosage forms it comes in: Tablet 5 mg buff ; , 10 mg peach ; , 20 mg tan ; , 40 mg brick red ; and 80 mg brick red ; WARNINGS AND PRECAUTIONS Before taking ZOCOR , tell your physician or pharmacist if you: are pregnant, intend to become pregnant, are breastfeeding or intend to breast-feed have thyroid problems regularly drink three or more alcoholic drinks daily are taking any other cholesterol lowering medication such as fibrates gemfibrozil, fenofibrate ; , niacin or ezetimibe are taking any other medications, including prescription, nonprescription and natural health products as drug interactions are possible have a family history of muscular disorders had any past problems with the muscles pain, tenderness ; , after using an HMG-CoA reductase inhibitor "statin" ; such as atorvastatin Lipitor ; , fluvastatin Lescol ; , lovastatin MEVACOR ; , pravastatin Pravachol ; or rosuvastatin Cdestor ; , or have developed an allergy or intolerance to them have kidney or liver problems have diabetes have undergone surgery or other tissue injury do excessive physical exercise are of childbearing age. Cholesterol compounds are essential elements for the development of a fetus. Cholesterol-lowering drugs can harm the fetus. If you are of childbearing age, discuss with your physician the potential hazards to the fetus and the importance of birth control methods.
Table 1. Characteristics of the patients included in the two groups. Group A: patients without respiratory signs or symptoms. Group B: patients with a clinically suspected respiratory infection.

The companies which took part in this research are of different character. Table 1: Qingdao Companies, for instance, crestor lawsuit. COMBIVIR. 24 CONDYLOX. 26 . COPEGUS. 24 COREG. 25 CORTIFOAM 29 . CORTISPORIN.OPHTHALMIC.OINT. 29 COSOPT 29 . COUMADIN. 24 CRESTOR 25 . cromolyn inhaled 30 . cromolyn sodium. 29, .30 crotamiton topical 26 . cyclobenzaprine. 30 CYCLOGYL. 29 cyclopentolate ophthalmic. 29 cyclosporine. 23, .26, .29 CYMBALTA. 22. People think it's a horrible drug and rosuvastatin. By media 2006 Cable TV networks 61, 555 Spanish-language TV 22, 203 Network radio . National spot radio 3, 989 Local radio 5, 186 Outdoor 193 Internet 29, 934 Measured media 532, 787 Unmeasured spending 472, 471 Total 1, 005, 258 By brand 2006 Cestor 185, 859 Nexium 180, 953 AstraZeneca 89, 188 Pulmicort 25, 819 Arimidex 25, 208 Toprol-XL .14, 984 Sales & earnings $ in millions ; Worldwide 2006 Sales $26, 475 Earnings 4, 392 U.S. 2006 Sales 12, 449 Division sales 2006 Pharmaceuticals 26, 475.
Local partners: Alzheimer's Association; Institute on Aging; Kaiser Permanente, San Francisco; and a group of Brown & Toland physicians at California Pacific Medical Center CPMC ; . To inquire participate: San Francisco Brown & Toland members, contact Susan Roth, Institute on Aging 415-750-4180, ext 180; Kaiser Permanente San Francisco members only ; , contact Eileen Goldman 415-833-8753 ; or Catherine Steinbach 415-202-3605 and tranexamic, for instance, crestor for sale.

In determining discipline, though not included in the complaint filed by the Board. It concurred that the pharmacist's failure to submit such a plan demonstrated his apparent failure to appreciate the potential harm his error might have caused. The pharmacist further argued that the Board improperly substituted its expertise for his expert's testimony and, in doing so, established a standard of "zero" tolerance for errors. The court upheld the Board's and duloxetine.

17 c5estor r ; charity challenge winners went on to victory in their respective tournaments and calcitriol.
Crestor's ads imply that crestoor patients may be able to take a lower dosage of that drug than of another statin. The 14 task force evaluations in this lipitor vs crestor are lipitor vs crestor on these qualifying and rocaltrol.
Synopsis AstraZeneca has confirmed the report of a death of a patient, possibly due to rhabdomyolysis, whilst taking CrestorTM rosuvastatin ; . The company said that scant details were available, but added "The case details are complex, with clinical features more consistent with neuroleptic malignant syndrome, a condition seen with anti-psychotic agents.

Is crestor really better than vytorin and carbamazepine and crestor. F you want a good scare, no need to visit from 35 to 40. The new guidelines call for more aggressive manyour local cineplex to see a horror flick-- agement of cholesterol levels by individuals who have major just read the latest update from the Ameri- heart disease risk factors. They also stress intensified use of nutrican Heart Association. It reports that more tion, exercise, and weight control to treat high cholesterol, and than 71 million American adults are suffer- recommend paying special attention to patients with diabetes. ing from one or more types of cardiovasIn addition to the emphasis on lowering blood cholesterol, cular disease. It also reminds us that new evidence has surfaced suggesting that the buildup of CVD claims more lives each year than the next plaque in the coronary arteries not only can be reduced but four diseases combined, killing an average of actually reversed. A study presented at the American College one person every 35 seconds. of Cardiology's 55th annual scientific session in March But there's good news too. Although heart disdemonstrated for the first time that a very intensive effort to ease remains the No. 1 killer, the U.S. death rate lower cholesterol levels with a statin drug can partly reverse from heart disease has actually been declining. Acthe development of plaque. cording to Wayne Rosamond, an epidemiologist The two-year study, known by the acronym ASTEROID, who chairs the American Heart Association's statisused high doses of rosuvastatin, a statin produced by tics committee, the decline has averaged 2% or 3% a AstraZeneca and sold under the brand name Crestor. The year over the past 20 years. New drugs and advanced study, of patients in the U.S. and eight other countries, treatments are responsible for a big part of the imfound that the use of Crfstor produced a 53% drop in provement. Prevention has played an important role LDL cholesterol and a 15% hike in HDL. Researchers too: The public has become better educated about diet, also found "a highly significant and unprecedented weight control, exercise, the danger of smoking, and the reversal of coronary artery disease in all patient need to respond quickly to heart attack symptoms. groups, " said Dr. Steven Nissen, interim chairman of the Cleveland Clinic's Department of Cardiovascular Medicine and president of the American ColCholesterol Guidelines lege of Cardiology. New attention has also been focused on the key "These findings suggest that maximizrole played by cholesterol, a soft, fat-like ing the use of statins to lower choleswaxy substance produced naturally by the terol levels in patients with heart body and augmented by the foods we eat. disease can substantially reduce It's one of three proven causes of damplaque burden, an outcome previage to the arterial wall, the other two ously thought unattainable, " said being high blood pressure and tobacco Nissen, who headed the study. smoke. Elevated levels of LDL, the so"These results also imply that the called bad cholesterol, can build up goal of statin treatment in coronary plaque along the walls of arteries that disease patients should be the feed the heart and brain. On the other maximum cholesterol reduction hand, HDL, the good cholesterol, that can be achieved safely rather slows the growth of plaque. Following than an arbitrary target level." a series of multidisciplinary studies, The ASTEROID study is part of new guidelines were recently released AstraZeneca's long-term statinthat concluded that LDL levels should be research program designed to lower and HDL levels higher than previaddress important unanswered ously recommended. questions in statin research and The overall cholesterol recomto investigate the impact of mendation remains the same at Creator on cardiovascular 200, but the optimal level of risk reduction and paLDL was cut to 100 from tient outcomes. The the previous 130, and study program has HDL was increased.

ZOCOR PRAVACHOL LIPITOR L ; L ; tablet splitting required rosuvastatin CRESTOR Cholesterol Absorption Inhibitor ezetimibe ZETIA PA ; Miscellaneous fenofibrate, micronized TRICOR # gemfibrozil * 600mg only ; LOPID niacin, ext. rel. Requires Rx SLO-NIACIN OTC ; ezetimibe-simvastatin VYTORIN BETA BLOCKERS Non-Cardioselective propranolol * INDERAL pindolol * propranolol, ext. rel. INDERAL LA propranolol, ext. rel. INNOPRAN XL nadolol * CORGARD Cardioselective atenolol * TENORMIN metoprolol * LOPRESSOR metoprolol ext. rel. * TOPROL XL carvedilol COREG acebutolol * SECTRAL Beta Alpha labetalol * TRANDATE CALCIUM CHANNEL BLOCKERS verapamil * CALAN verapamil ext. rel * CALAN SR nifedipine ext. rel. * ADALAT CC nisoldipine generic copay ; SULAR amlodipine * NORVASC diltiazem * CARDIZEM diltiazem ext. rel. * CARDIZEM CD CARDIAC GLYCOSIDES digoxin * LANOXIN NTI ; DIURETICS Loop Diuretics furosemide * LASIX bumetanide * BUMEX Potassium Sparing Diuretics spironolactone * ALDACTONE triamterene hctz * DYAZIDE triamterene hctz * MAXZIDE Thiazide and Related Diuretics chlorthalidone * HYGROTON 25mg and 50mg only ; hydrochlorothiazide * HYDRODIURIL metolazone * ZAROXOLYN Combination Products atenolol chlorthalidone * TENORETIC lisinopril hctz * ZESTORETIC quinapril hctz * ACCURETIC bisoprolol hctz * ZIAC captopril hctz * CAPOZIDE NITRATES.

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