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By Lorraine McQueen, Richmond, VA I writing to urge each and every FA family to raise funds for the FA Research Fund. Our son, Sean, was diagnosed with FA on October 18, 1999 you never do forget the "diagnose day, " do you? ; . Like most families, our first reaction to the news was disbelief. As much as my husband and I tried to convince ourselves that it just couldn't be, we both knew it was true. Finally, all of the pieces to Sean's unique medical puzzle fit. At first we just cried a lot. We were completely at a loss as to how we should live our lives and felt immobilized by the diagnosis. We were forever coming up with lists of questions that no one could answer. Our doctors told us that because Sean is mosaic, he "should be fine" so we should "just wait and see how he does." I remember hearing the doctor telling us to "wait and see" and thinking, "If you knew a train was going to come speeding along and hit you, would you just "wait and see" what happened when it did? We knew it was time for action! There are so many aspects of this disease that are beyond our control. However, we, as parents of these fantastic FA kids, are not powerless! One important way that each and every one of us can engage in battle against this disease is to raise funds for the FA Research Fund. FARF is our best hope of finding a cure. Our first fundraising effort was a letter writing campaign. At first we felt a bit uncomfortable about the idea of writing a letter to all of our family and friends to ask them for money. We knew, though, that letting our pride. PAIN--COMMON AND LIFE-ALTERING Fifty-two women and 11 men with MS completed a mailed packet of questionnaires asking about the types, frequency, and severity of any pain that they experienced. Overall, 97% indicated that they had some type of pain and 80% reported MS-related pain. "Paroxysmal limb pain-- sharp, shooting pains in the legs, hands, and sometimes the trunk-- was most common, occurring in 63% of patients, " noted Dr. Griswold, formerly a researcher at the Bernard W. Gimbel MS Center in Teaneck, New Jersey and now with Bellevue Hospital in New York City. "Dysesthetic extremity pain, which is similar but duller and more chronic in nature, was second most common at 52%" Table ; . Also, 40% of patients said that they had headaches and 83% reported more than one kind of pain and evista and cyclobenzaprine, because what does cyclob4nzaprine look like. Bencoprim cyclobsnzaprine hcl Brazil makes eight aids drugs starting in 1994, brazil's government urged local firms to start making drugs to treat aids. 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Changes in accounting for expensing of stock options could result in unfavorable charges or require us to change our compensation policies. We have relied heavily on stock options to compensate existing employees and attract new employees. We currently are not required to record stock-based compensation charges if the employee's stock option exercise price equals or exceeds the fair value of our common stock at the date of grant. In December 2004, the Financial Accounting Standards Board "FASB" ; issued SFAS No. 123 Revised ; , Share-Based Payment. This Statement is a revision of SFAS No. 123, Accounting for Stock-Based Compensation, and supersedes APB Opinion No. 25, Accounting for Stock Issued to Employees, and its related implementation guidance. SFAS No. 123 Revised ; focuses primarily on accounting for transactions in which an entity obtains employee services in share-based payment transactions. The Statement requires entities to recognize stock compensation expense for awards of equity instruments to employees based on the grant-date fair value of those awards with limited exceptions ; . SFAS No. 123 Revised ; is effective as of the beginning of the first interim or annual reporting period that begins after June 15, 2005. Management of the Company is evaluating the two methods of adoption allowed by SFAS No. 123 Revised ; , the modified-prospective transition method and the modified-retrospective transition method, and the related impact on our Consolidated Financial Statements. When we change our accounting policy to record the fair value of stock options granted, our expenses will increase which will reduce our net income and earnings per share. We may choose to reduce our reliance on stock options as a compensation tool as a result of the impact of recording stock options at their fair value. If we reduce our use of stock options, it may be more difficult for us to attract and retain qualified employees. If we cannot attract and retain key personnel, we may not be able to execute our business plan as anticipated. Our success is dependent on our ability to attract and retain qualified, experienced personnel. We face significant competition in recruiting competent personnel. Because the location of our headquarters is in an area with relatively few pharmaceutical companies recruiting candidates has been more difficult, as many candidates prefer to work in places with a broad pharmaceutical industry presence. The loss of key personnel, or the inability to attract and retain additional, competent employees, could adversely affect our business and financial results. We have assigned many key responsibilities within our company to, and are dependent on, a relatively small number of individuals. If we lose the services of our Chief Executive Officer, Chief Financial Officer, Chief Medical Officer, or the General Manager of our Spanish subsidiary, our ability to execute our business plan in the manner we currently anticipate would be adversely affected. We maintain key person life insurance only for our Chief Executive Officer. We have an employment agreement with each of our key personnel. Be considered for any toxic wide-complex tachycardia. Sodium bicarbonate reverses the membrane stabilizing effects of various toxins and counteracts QRS widening as well as AV block and hypotension. The goal is an arterial pH of 7.50 to 7.55. Bicarbonate should be considered in the following overdoses: TCA's, cyclobenzaprine, orphenadrine, procainamide, disopyramide, quinidine, quinine, chloroquine, encainide, flecainide, propafenone, mexiletine, amantadine, thioridazine, mesoridazine, carbamazepine, cocaine, bupivacaine, propoxyphene, diphenhydramine, chlorpheniramine, pyrilamine, arsenic, and taxine yew plant ingestion ; . Another antidysrythmic drug to consider in toxin-induced VT or VF is magnesium sulfate, especially when QT prolongation is present. The dose is 2 grams in adults and 25 mg kg in children, administered over 2 minutes. 10. Pacemakers are definitely out for treating bradyarrhythmias secondary to digitalis toxicity. Studies have shown a high complication rate--36 percent--when pacemakers are used, because the myocardium is already irritable. Pacemakers may still be needed for treating bradycardias from beta blocker and calcium channel blocker overdose. Digoxin-specific Fab fragments Digibind or Digifab ; are definitely in for the treatment of digitalis intoxication. In the past they were reserved for immediately life threatening arrhythmias, but should probably be given earlier. Digibind does not work as quickly as naloxone Narcan ; . It takes many minutes rather than seconds and definitely should be given whenever pacing is considered. Another indication is a potassium level greater than 5.0, since rising potassium correlates highly with increasing mortality. 11. Several killing combinations of drugs have been recognized and should be avoided. First, never combine a MAO inhibitor with a selective serotonin re-uptake inhibitor SSRI ; such as Prozac, or with meperidine, tramadol, dextromethorphan or codeine. The combination can result in the deadly Serotonin Syndrome, marked by the rapid onset of rigidity, hyperthermia and altered level of consciousness. MAOI's include Marplan isocarboxyazid ; , Nardil phenelzine ; , Parnate tranylcypromine ; , and Eldepryl selegiline ; . Allow at least a two-week washout between MAOI's and SSRI's, TCA's and other antidepressants. Repeated use of meperidine also results in accumulation of its toxic metabolite, normeperidine, which causes seizures. Because of meperidine's drug interactions and toxicity, it may be best to avoid its use entirely in emergency medicine. Second, avoid beta blockers in the setting of cocaine intoxication, especially in patients complaining of chest pain. The combination has been shown to increase blood pressure and cause coronary artery vasoconstriction from unopposed alpha stimulation. In the setting of a cocaine-associated myocardial infarction, benzodiazepines and nitroglycerin should be used first. If chest pain persists, then 1 mg of phentolamine can be given IV. 12. Ethanol is out for the treatment of ethylene glycol EG ; and methanol poisoning. These chemicals are common ingredients of windshield washer fluid as well as radiator and gas line antifreeze.Though inexpensive, ethanol usually made patients sick and children hypoglycemic ; , and it was difficult to maintain therapeutic levels. Fomepizole Antizol * ; was approved by the FDA in late 1997 for the treatment of EG poisoning, and in early 2001 for the treatment of methanol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, which catalyzes the metabolism of ethylene glycol--itself non-toxic--to toxic metabolites such as glycolic, oxalic, and other acids, which cause a high anion gap acidosis and renal failure. Alcohol dehydrogenase also catalyzes the conversion of methanol to formic acid, which damages the optic nerve, causing blindness. Fomepizole is indicated for suspected EG and methanol poisoning or for levels 20 mg dl. Hemodialysis is still recommended for patients whose level exceeds 50 mg dl. Many case reports and future studies will probably confirm the safety and effectiveness of fomepizole alone for treatment of patients with higher levels of EG or methanol. 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