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The pursuit of the neuropathological basis of schizophrenia has produced so many findings often not replicated or contradicted by other findings ; that it is known as "the graveyard of neuropathologists." Curiously, during at least the first half of the 20th century it was the more "progressive" in the field who questioned these organic theories, partially out of concern that they lead to therapeutic nihilism and despair. Today, if we can believe the advocates, changing the nomenclature to brain disease will inspire society to provide expensive care and instill hope in those afflicted. Possibly the search for the neuropathological basis of these illnesses is ill informed because it denies the unique nature of brain anatomy. When I attended medical school, the first year of anatomy covered the whole body except the brain, and the second year was spent learning neuroanatomy. This is because the anatomy of other organs is relatively homogeneous one part of the heart, kidneys, or liver is pretty much like another part ; , because all the parts of these organs do pretty much the same thing contract to pump blood, metabolize toxins, excrete waste products ; . Also, we generally understand how these organs function their physiology ; and therefore understand their dysfunction in illness their pathophysiology ; . The brain is extraordinarily complex anatomically, with different areas having very different functions. Furthermore, although we know a good deal about how these areas are connected and how nerves communicate, we have little understanding of how this communication produces thoughts or complex behaviors. In neurologic illnesses, specific deficits in sensation, motor activity, or cognitive processing can be ascribed to particular areas of the brain. 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