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P137 VISUAL FIELD CONSTRICTION ASSOCIATED WITH VIGABATRIN: RETINAL NERVE FIBER LAYER PHOTOGRAPHIC CORRELATION Dong Myung Kim, Hyuk Jin Choi Department of Ophthalmology, Seoul National University Hospital, Seoul, Korea PURPOSES To report retinal nerve fiber layer RNFL ; photographic change in a patient with prolonged vigabatrin therapy. METHODS An 18-year-old male who has taken vigabatrin for complex partial seizure was referred for the ophthalmic examination. The cumulative dose of vigabatrin was about 6.0 Kg during 7 1 2 years. He had no subjective visual symptom. But central 30-2 threshold test using Humphrey Field Analyzer showed bilateral symmetric visual field constriction with greater loss of the nasal visual field. Electroretinography ERG ; , electrooculography EOG ; , visual evoked potential VEP ; and RNFL thickness analysis around the disc by optical coherence tomography OCT ; as well as RNFL photography were performed for the evaluation of his visual function. RESULTS In both eyes, visual acuity was 20 16 and intraocular pressure measured by applanation tonometry was normal. ERG and EOG showed normal results, but VEP showed decreased peak amplitude and normal latency in both eyes. On the RNFL photograph, there was discernible RNFL loss in the peripheral retina and relative preservation of papillomacular bundles. RNFL thickness around the optic disc measured by OCT was markedly reduced in all quadrants except for the temporal quadrant in both eyes and the inferior quadrant in the right eye. These findings correlate with concentric visual field loss and suggest that the primary site of injury lies within the ganglion cells in the retina and visual field loss is irreversible. CONCLUSIONS RNFL photography could be a valuable tool in evaluating damage of visual function due to prolonged vigabatrin therapy for epilepsy. 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